主题：致萨苏：我虽然和你没什么交情，但想提醒你一句，不要被人利用 -- woodbear

Shi Haichao; Huang Qiuyun (Osaka Prefecture University) (Fuzhou Free Medical Treat Second Out Patient Department)

　In this paper, we reported the extract of Sphora susprostrata Kugua radix (also called Kugua extract)preyented marked1y the Streptozotocin-induced diabetic rats from getting cataracts. In practice, Kugua extract inhibited aldose reductase (AR ) that is a key enzyme of the pathway of glucose metabolism to convert glucose to sorbitol. In vitro,Human Recombinant AR was most effectively inhibited by Kugua extract,it has competitive inhibition on the Human Recombinant AR and on the (±) glyceraldehyde as substrate,and has non-competitive inhibition on the NADPH as coenzyme. It suggested that Kugua extract can be used to treat and prevent the diabetogenous cataract.

【Keyword】：Kugua extract Anti cataract activity Kugua isoflavone glycosides Anti-diabetic and diabetogenous diseases