主题:【原创】说说糖尿病, 地震和血糖 (上)(增补一个试验) -- wan1234

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家园 哈哈,我也喜欢掐

只要能言之有物,学到东西,交了朋友,好事一件啊。

short term,long term stress 参考美国糖尿病学会关于stress的介绍。

Stress results when something causes your body to behave as if it were under attack. Sources of stress can be physical, like injury or illness. Or they can be mental, like problems in your marriage, job, health, or finances.

When stress occurs, the body prepares to take action. This preparation is called the fight-or-flight response. In the fight-or-flight response, levels of many hormones shoot up. Their net effect is to make a lot of stored energy - glucose and fat - available to cells. These cells are then primed to help the body get away from danger.

In people who have diabetes, the fight-or-flight response does not work well. Insulin is not always able to let the extra energy into the cells, so glucose piles up in the blood.

Many sources of stress are not short-term threats. For example, it can take many months to recover from surgery. Stress hormones that are designed to deal with short-term danger stay turned on for a long time. As a result, long-term stress can cause long-term high blood glucose levels.

Many long-term sources of stress are mental. Your mind sometimes reacts to a nondangerous event as if it were a real threat. Like physical stress, mental stress can be short term - from taking a test to getting stuck in a traffic jam. It can also be long term: from working for a demanding boss to taking care of an aging parent. In mental stress, the body pumps out hormones to no avail. Neither fighting nor fleeing is any help when the "enemy" is your own mind.

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It's easy to find out whether mental stress affects your glucose control. Before checking your glucose levels, write down a number rating your mental stress level on a scale of 1 to 10. Then write down your glucose level next to it. After a week or two, look for a pattern. Drawing a graph may help you see trends better. Do high stress levels often occur with high glucose levels, and low stress levels with low glucose levels? If so, stress may affect your glucose control.

回头看施博士是如何解释的“地震糖尿病”:超负荷的心理负担和刺激令胰岛的a细胞分泌量超出β细胞处理能力的高血糖素,而引起糖尿病。地震引起的超负荷的心理负担和刺激容易理解(至少也表明他不是在说地震引起了糖尿病),后面那些我不懂,你要么说说?青方医生的BLOG中对这个机制是这么说的,“胰岛细胞有四种,分泌胰高血糖素的是a细胞,分泌胰岛素的是b细胞。因为研究上的困难,胰高血糖素的分泌调节不是很清楚。有报道,胰高血糖素受体敲除的老鼠,血液中胰高血糖素水平异常升高,但老鼠并没有得糖尿病,说明施教授的这个解释,从学术角度看还是很值得商榷的。”

山寺桃花提到一篇review 在讨论自然灾害造成的生理心理压力对健康的影响.糖尿病发生危险系数豁然在内,是显著性提高了。你觉得机制又是如何?

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