五千年(敝帚自珍)

主题:【原创】中药小故事之八——全蝎 -- 快刀浪子

共:💬34 🌺79
全看分页树展 · 主题 跟帖
家园 蝎毒有学问

点看全图

外链图片需谨慎,可能会被源头改

This protein is scorpion toxin II from Androctonus austalis. It is a 64 residue protein that binds to mammalian sodium channels, causing paralysis and death at high enough doses. Most of the residues indicated to be crucial to binding to sodium channels are located on a knob at the lower left of the image. Positively charged amino acids are shown in red. Arg 62 and His 64 protrude furthest from the core of the protein. It is reasonable to expect such residues to be involved in binding to sodium channels, which usually handle positively-charged Na+ ions. Mutational analysis has shown that Asp 8 (blue) and Lys 58 (green) are likely to be critical to binding. Arg 18 is not in the same region as the rest of the binding residues, but probably has a major role in binding also. The purple segment is residues 9 through 12, which together with residue 8, form a structurally conserved loop found in many scorpion toxins. This image was made by J High, School of Biology, Georgia Tech, 1998.

点看全图

外链图片需谨慎,可能会被源头改

全看分页树展 · 主题 跟帖


有趣有益,互惠互利;开阔视野,博采众长。
虚拟的网络,真实的人。天南地北客,相逢皆朋友

Copyright © cchere 西西河