主题：【原创】关于针灸问题的基点说明 -- 虽远必诛

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

腺苷A1型受體介導了針灸的局部抗神經毒作用

Abstract

摘要

Acupuncture is an invasive procedure commonly used to relieve pain.

針灸是一種通常用於止痛的侵入性療法。

Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine.

儘管難於將其理論與實證醫學折沖調和，針灸依然在世界範圍內被廣泛應用。

We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression.

我們發現，在對小鼠的針灸過程中，腺苷（adenosine）作為一種神經調製因子被釋放（於神經細胞間隙）並用來拮抗神經毒的作用；這種拮抗神經毒的作用需要神經細胞表達一種被稱為腺苷A1型受體Adora1的蛋白。

Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture.

在小鼠中身體上直接注射Adora1這個受體的激活劑，這個實驗再現了針灸的鎮痛效應。

Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect.

反之，抑制參與降解腺苷的酶則促進了（針灸產生的）腺苷的積累；同樣，腺苷對神經毒的拮抗也增加了。

These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.

這些觀察結果表明，腺苷介導了針灸鎮痛的功能；而且，針灸在臨床應用中或許更會得益於進一步干擾腺苷的代謝。