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主题:我国部分地区大老鼠绝迹 被指与转基因玉米有关 -- 破鱼

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家园 老鼠变小了的一个可能解释与epigenetics

The New 'Epigenetics:' Poor Nutrition In The Womb Causes Permanent Genetic Changes In Offspring

In the research report, scientists from the University of Utah show that rat fetuses receiving poor nutrition in the womb become genetically primed to be born into an environment lacking proper nutrition.

As a result of this genetic adaptation, the rats were likely to grow to smaller sizes than their normal counterparts. At the same time, they were also at higher risk for a host of health problems throughout their lives, such as diabetes, growth retardation, cardiovascular disease, obesity, and neurodevelopmental delays, among others. Although the study involved rats, the genes and cellular mechanisms involved are the same as those in humans.

The scientists made this discovery through experiments involving two groups of rats. The first group was normal. The second group had the delivery of nutrients from their mothers' placentas restricted in a way that is equivalent to preeclampsia. The rats were examined right after birth and again at 21 days (21 days is essentially a preadolescent rat) to measure the amount of a protein, called IGF-1, that promotes normal development and growth in rats and humans. They found that the lack of nutrients caused the gene responsible for IGF-1 to significantly reduce the amount of IGF-1 produced in the body before and after birth.

一言以蔽之,如果老鼠在胚胎发育时期营养不良,其出生后基因会发生永久性改变,使其体型变小。

哈佛医学院十月六日有关于epigenetics的免费讲座:October 6 You Are What Your Mother Ate: The New Science of Epigenetic

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